The solution

abcdefghijklmnopqrstuvwxyz
=

[The quiz]
A quiz by RJG: Os + V + Xe + Cl + Fm + ? = K + Pd + W + Th + N + ?
=

[The solution]
A RJG quiz: Os + V + Xe + Cl + Fm + B = K + Pd + W + Th + N + Y

[Atomic numbers add up to 275:]
76 + 23 + 54 + 17 + 100 + 5 = 19 + 46 + 74 + 90 + 7 + 39

[Letters (using A=1, B=2, etc) add up to 121:]
(15+19) + 22 + (24+5) + (3+12) + (6+13) + 2 = 11 + (16+4) + 23 + (20+8) + 14 + 25